Thymoquinone

RESEARCH PAPERS

Thymoquinone and COVID-19
  1. Sawsan Elgohary, Aya A. Elkhodiry, Nada S. Amin, Ulrike Stein and Hend M. El Tayebi Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients, February 2021 Cells 10(2):302 DOI:10.3390/cells10020302

Link to article: https://www.researchgate.net/publication/348974732_Thymoquinone_A_Tie-Breaker_in_SARS-CoV2-Infected_Cancer_Patients

  1. Ahmet Feridun Isik, Ismail Kati, Irfan Bayram, Hanefi Ozbek, A new agent for treatment of acute respiratory distress syndrome: thymoquinone. An experimental study in a rat model, Eur J Cardiothorac Surg 2005 Aug;28(2):301-5. doi: 10.1016/j.ejcts.2005.04.012.

Link to article: https://pubmed.ncbi.nlm.nih.gov/15949945/#:~:text=Thymoquinone%20has%20anti%2Dinflammatory%2C%20spasmolytic,gastric%20juice%20(pH%201.2)

  1. Sommer, Andrei P., Horst-Dieter Försterling, and Kurt G. Naber. "Thymoquinone: shield and sword against SARS-CoV-2." Precision Nanomedicine (2020): 541-548.

Link to articlehttps://precisionnanomedicine.com/article/12984-thymoquinone-shield-and-sword-against-sars-cov-2

  1. Sommer AP, Försterling HD, Sommer KE. Tutankhamun's Antimalarial Drug for Covid-19 [published online ahead of print, 2020 Oct 30]. Drug Res (Stuttg). 2020; doi:10.1055/a-1274-1264

Link to article: https://www.thieme-connect.de/products/ejournals/html/10.1055/a-1274-1264

  1. Farmanli O, Bastug S, Donmez OF, et al. A Traditional Medicine, Nigella Sativa Can Be Effective on Novel Coronavirus (Sars-Cov-2) and Pulmonary Diseases (Hypothesis). SOJ Pharm Sci. 2020; 7(1):1-5. DOI: 10.15226/2374-6866/7/1/001100

Link to articlehttps://symbiosisonlinepublishing.com/pharmacy-pharmaceuticalsciences/pharmacy-pharmaceuticalsciences100.pdf

  1. Islam MN, Hossain KS, Sarker PP, et al. Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure. Phytother Res. 2020 Oct 12. doi: 10.1002/ptr.6895. Epub ahead of print. PMID: 33047412.

Link to articlehttps://onlinelibrary.wiley.com/doi/10.1002/ptr.6895

  1. Ahmad A, Rehman MU, Ahmad P, Alkharfy KM. Covid-19 and thymoquinone: Connecting the dots. Phytother Res. 2020 Jun 26:10.1002/ptr.6793. doi: 10.1002/ptr.6793. Epub ahead of print. PMID: 32588453; PMCID: PMC7361316.

Link to articlehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361316/

 

Therapeutic Actions of Thymoquinone
  1. Younus, H., 2018. Molecular & Therapeutic Actions of Thymoquinone. 1st ed. Singapore: Springer, pp.1-85.

Link to bookhttps://www.springer.com/gp/book/9789811087998

  1. Fröhlich T, Reiter C, Saeed MEM, et al. Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents. ACS Med Chem Lett. 2017;9(6):534-539. Published 2017 Dec 21. doi:10.1021/acsmedchemlett.7b00412

Link to articlehttps://pubmed.ncbi.nlm.nih.gov/29937978/

  1. Majdalawieh AF, Fayyad MW. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. Int Immunopharmacol. 2015 Sep;28(1):295-304. doi: 10.1016/j.intimp.2015.06.023. Epub 2015 Jun 26. PMID: 26117430.

Link to article: https://www.sciencedirect.com/science/article/pii/S1567576915300011?via%3Dihub

  1. Khither H, Sobhi W, Khenchouche A, et al. In-vitro Antioxidant Effect of Thymoquinone. Annual Research & Review in Biology. 2018 Apr 10:1-9.

Link to articlehttps://www.journalarrb.com/index.php/ARRB/article/view/25116

  1. Forouzanfar F, Bazzaz BS, Hosseinzadeh H. Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects. Iran J Basic Med Sci. 2014;17(12):929-938.

Link to article:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387228/

  1. Amin B, Hosseinzadeh H. Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects. Planta Med. 2016;82(1-2):8-16. doi:10.1055/s-0035-1557838

Link To article: https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0035-1557838

  1. Tavakkoli A, Mahdian V, Razavi BM, et al. Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone. J Pharmacopuncture. 2017;20(3):179-193. doi:10.3831/KPI.2017.20.021

Link to articlehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633670/

  1. Shaterzadeh-Yazdi H, Noorbakhsh MF, Hayati F, et al. Immunomodulatory and Anti-inflammatory Effects of Thymoquinone. Cardiovasc Hematol Disord Drug Targets. 2018;18(1):52-60. doi:10.2174/1871529X18666180212114816

Link to article: https://pubmed.ncbi.nlm.nih.gov/29437018/

  1. Umar S, Shah MAA, Munir MT, et al. RETRACTED: Synergistic effects of thymoquinone and curcumin on immune response and anti-viral activity against avian influenza virus (H9N2) in turkeys. Poult Sci. 2016;95(7):1513-1520. doi:10.3382/ps/pew069

Link to article: https://www.sciencedirect.com/science/article/pii/S0032579119318474?via%3Dihub

  1. Noorbakhsh MF, Shaterzadeh-Yazdi H, Hayati F, Samarghandian S, Farkhondeh T. Protective Effects of Thymoquinon on Pulmonary Disorders in Experimental Studies. Tanaffos. 2018;17(4):211-222.

Link to article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534803/

  1. Khader M, Eckl PM. Thymoquinone: an emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci. 2014;17(12):950-957.

Link To article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387230/

  1. Darakhshan S, Bidmeshki Pour A, Hosseinzadeh Colagar A, Sisakhtnezhad S. Thymoquinone and its therapeutic potentials. Pharmacol Res. 2015;95-96:138-158. doi:10.1016/j.phrs.2015.03.011

Link To article: https://www.sciencedirect.com/science/article/abs/pii/S104366181500050X?via%3Dihub

  1. Molla, S., Azad, A. K., Al Hasib, A. A., Hossain, M. M., Ahammed, S., & Rana, S. (2019). A review on antiviral effects of Nigella sativa L. PharmacologyOnline, Newsletter, 2: 47-53.

Link to article: https://pharmacologyonline.silae.it/files/newsletter/2019/vol2/PhOL_2019_2_NL007_Molla.pdf

 

Therapeutic Potential of N. Sativa oil/Seed
  1. Ahmad A, Husain A, Mujeeb M, et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013;3(5):337-352. doi:10.1016/S2221-1691(13)60075-1

Link to article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/

  1. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012;26(8):1246-1248. doi:10.1002/ptr.3679

Link to article:  https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.3679

  1. Khan MA, Chen HC, Tania M, Zhang DZ. Anticancer activities of Nigella sativa (black cumin). Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):226-232. doi:10.4314/ajtcam.v8i5S.10

Link To article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252704/



Various Online database for Thymoquinone/N. Sativa related information
  1. Articles related to Thymoquinone and Covid 19 in Pubmed database: https://pubmed.ncbi.nlm.nih.gov/?term=thymoquinone+covid19&sort=date
  2. Ongoing/completed Clinical Trials of Thymoquinone: https://clinicaltrials.gov/ct2/results?cond=Thymoquinone
  3. Ongoing/completed Clinical Trials of N. Sativa : https://clinicaltrials.gov/ct2/results?term=Nigella+Sativa
  4. CTRI (clinical trial registry of India) database:
    1. http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43378&EncHid=&userName=thymoquinone
    2. http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=28562&EncHid=&userName=thymoquinone